ENDOMETRIOSIS: DUPHASTON THERAPY

Side effects of Duphaston

Most women using Duphaston only experience one or two mild side effects which sometimes settle with time.

The most common side effects that have been reported include breast tenderness, weight gain, bloating, depression, headaches, lethargy and tiredness, dizziness, nausea, irregular vaginal bleeding and cramps.

The side effects of Duphaston are reversible and they diminish soon after treatment ceases.

There are no known long-term side effects of Duphaston therapy.

How effective is Duphaston

It is extremely difficult to provide any figures regarding the effectiveness of Duphaston in the treatment of endometriosis as there has been almost no research published on the issue. Duphaston has been used as a treatment for endometriosis for many years and it has shown itself to be an effective treatment for many women. One unpublished Australian study suggests that nine months treatment with Duphaston is as effective as six months treatment with Danazol.

The only study published to-date found that 43 of the 49 women had complete or partial relief from their symptoms and of the 19 women with infertility who wished to conceive, 10 did so.

There is no information available on the recurrence rate of endometriosis following treatment with Duphaston.

Duphaston, pregnancy and breastfeeding

The manufacturers of Duphaston state that it should not be used during pregnancy as progestogens may cause abnormalities in the developing foetus.

The use of Duphaston while breastfeeding is not recommended by the manufacturers. Small amounts of progestogens have been found in the milk of mothers taking the drug and effects on the child are unknown. However, some gynecologists believe that Duphaston can be safely used during pregnancy or breastfeeding.

Interaction with other drugs, alcohol or foods

There are no known interactions of Duphaston with any foods, alcohol or other drugs.

*39 /41/5*

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